HFIP-Promoted [ 18 F] trifluoromethylation via iodofluorination of gem -difluoroalkenes

Chemical Communications 2026

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Authors: Yuzhang, Yifan Ren, Junbin Han, Xiaojun Zeng
DOI: 10.1039/d6cc01326k
Cited by: 1
References: 38

Abstract

We report a hydrogen-bond-assisted strategy for the (radio)trifluoromethylation of gem -difluoroalkenes, enabling rapid access to α-iodo-[ 18 F]trifluoromethylated alkanes under mild and efficient conditions.

Fields of Study & Subjects

Fluorine in Organic Chemistry Chemical Reactions and Isotopes Medical Imaging Techniques and Applications

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
37
Pages
9419–9423
Publication date
1 January 2026
Language
EN