Design and application of amino acid-derived aromatic scaffolds in supramolecular covalent and non-covalent systems
Abstract
Amino acids represent versatile building blocks for the design of functional supramolecular architectures, combining inherent chirality with a rich palette of non-covalent interactions. In recent years, considerable effort has been devoted to integrating amino acid motifs into π-conjugated aromatic cores such as naphthalene diimides (NDIs), benzene-1,3,5-tricarboxamides (BTAs) and other synthetically accessible scaffolds. These systems exemplify the power of modular molecular design, where subtle variations in side chains or peptide fragments can precisely tune self-assembly pathways, supramolecular morphology and responsiveness to external stimuli. This feature article reviews the strategies and principles underlying the construction of amino acid-derived supramolecular assemblies, covering both non-covalent and dynamic covalent approaches.
Fields of Study & Subjects
Supramolecular Self-Assembly in Materials
Synthesis and Properties of Aromatic Compounds
Supramolecular Chemistry and Complexes
Publication details
- Journal / source
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 62
- Issue
- 45
- Pages
- 11245–11256
- Publication date
- 1 January 2026
- Language
- EN