Preactivation-free direct decarboxylative alkynylation of indoleacetic acids: access to alkynyl-functionalized indoles

Chemical Communications 2026

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Authors: Gui-Ting Song, Yuan Zhou, Xue-Ying Yang, Li-Min Zhang, Lan-Bin He, Li-Ping Qing, Cheng-Mi Lin, Zhuo-Er Chen, 屈川华
DOI: 10.1039/d6cc01731b
Cited by: 1
References: 66

Abstract

-hydroxyphthalimide ester preactivation or exogenous oxidants, and exhibits excellent substrate compatibility across diverse indoleacetic acids and terminal alkynes, delivering valuable alkynylated indole products in good to excellent yields. This approach fills a long-standing gap in decarboxylative coupling and provides a practical, atom-economical synthetic route to alkynyl indole scaffolds for pharmaceutical and materials applications.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Alkyne Reactions Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
39
Pages
9937–9941
Publication date
1 January 2026
Language
EN