Fe-catalysed chemoselective hydrogenation of maleimides to succinimides using water as the hydrogen source
Abstract
Herein, we demonstrated the first iron-catalysed chemoselective transfer hydrogenation of maleimides to succinimides using water as the hydrogen source and zinc as the reductant. A series of functionalized succinimides were obtained in excellent yield (41 examples, up to 95% yield). Preliminary mechanistic and deuterium-labelling studies including kinetic experiments were performed to establish the chemoselective hydrogenation.
Fields of Study & Subjects
Asymmetric Hydrogenation and Catalysis
Nanomaterials for catalytic reactions
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 62
- Issue
- 44
- Pages
- 11117–11120
- Publication date
- 1 January 2026
- Language
- EN