A spirocyclic BODIPY photosensitizer with pH-triggered triplet-state activation for tumor-selective photodynamic therapy

Chemical Communications 2026

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Authors: Luying Guo, Xing Guo, Yiran Liu, Heng Li, Huiquan Zuo, Shaozhen Wang, Lijuan Jiao, Erhong Hao
DOI: 10.1039/d6cc02143c
Cited by: 1
References: 67

Abstract

Conventional PDT photosensitizers generally suffer from inherent poor tumor selectivity. We herein develop a novel spirocyclic BODIPY-based photosensitizer (BDP-I) to exploit the weakly acidic tumor microenvironment for targeted selective activation. It enables efficient pH-triggered triplet-state ROS restoration and prominent tumor-selective phototoxicity, providing a promising molecular scaffold for precise tumor-acidity-targeted PDT.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Photodynamic Therapy Research Studies Luminescence and Fluorescent Materials

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
46
Pages
11687–11691
Publication date
1 January 2026
Language
EN