Unlocking a modular Gd-DOTBA platform via tetramaleimide click chemistry for high-performance MRI

Chemical Communications 2026

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Authors: Xinhui Xiao, Shiyao Wang, Peijie Guan, Zhiqiang Wang, Lixiong Dai
DOI: 10.1039/d6cc02219g
Cited by: 1
References: 26

Abstract

A tetramaleimide-functionalized Gd-DOTBA scaffold (Gd-DOTBA-Mal) is developed as a modular platform for high-performance MRI probes. The maleimide groups enable site-specific bioconjugation. A cysteine conjugate exhibits high relaxivity and stability, enabling sensitive kidney dysfunction assessment and tumor imaging at half the clinical dose. This versatile platform facilitates advanced molecular MRI development.

Fields of Study & Subjects

Lanthanide and Transition Metal Complexes Luminescence and Fluorescent Materials Supramolecular Chemistry and Complexes

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
46
Pages
11636–11640
Publication date
1 January 2026
Language
EN