Cooperative organelle targeting from a single molecular module: sterically hindered phenol–diaminopyridine–functionalized cycloalkynes for mitochondria–endoplasmic reticulum localization

Chemical Communications 2026

View at publisher
Authors: Aleksandra A. Vidyakina, Mia D. Kim, Sergey A. Silonov, Egor S. Galkin, Mariya A. Kryukova, Elmira Mingaleevna Gibadullina, Adel M. Shakirov, Alexandra Dmitrievna Voloshina, Elena Chugunova, Alexander Romanovich Burilov, Oleg Gerol'dovich Sinyashin, Irina A. Balova
+2 more Igor V. Alabugin, Natalia A. Danilkina
DOI: 10.1039/d6cc02377k
Cited by: 1
References: 55

Abstract

A modular approach for dual organelle targeting is developed using sterically hindered phenol-diaminopyridine-oxaazacyclononyne (SHP-DAP-OACN) thiourea-linked hybrids. These hybrids retain high reactivity in strain-promoted azide-alkyne cycloaddition, providing fluorescent triazoles with mitochondria and endoplasmic reticulum localization, suggesting SHP-DAP as a transferable module for organelle-directed probes.

Fields of Study & Subjects

Click Chemistry and Applications Synthesis and Properties of Aromatic Compounds Supramolecular Chemistry and Complexes

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
48
Pages
12152–12156
Publication date
1 January 2026
Language
EN