Photocatalyst-free EDA-complex-enabled radical difluoroalkylation/cyclization for access to difluoroalkylated polycyclic coumarin derivatives

Chemical Communications 2026

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Authors: Bei Liu, Yongmei Xiao, Lili Wang, Shilong Zhang, Meng Yan, Yuntao Xia, Jinwei Yuan
DOI: 10.1039/d6cc02524b
Cited by: 1
References: 86

Abstract

A photocatalyst-free and electron donor-acceptor (EDA)-complex-enabled radical difluoroalkylation/cyclization of unactivated alkenes with bromodifluoroacetamides has been developed for the efficient synthesis of difluoroalkyl-containing polycyclic coumarin derivatives, affording a total of 32 target compounds. In this transformation, persulfates act as electron donors and bromodifluoroacetamides serve as electron acceptors to generate an EDA complex, enabling visible-light-induced radical processes without the need for external photocatalysts. This method features mild reaction conditions, operational simplicity, metal-free nature, and broad functional group tolerance.

Fields of Study & Subjects

Fluorine in Organic Chemistry Radical Photochemical Reactions Photochromic and Fluorescence Chemistry

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
47
Pages
11891–11895
Publication date
1 January 2026
Language
EN