Synergistic cesium carbonate-promoted dehydration of ketonitrones: stereoselective synthesis of indenyl-2-azadienes

Chemical Communications 2026

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Authors: Meng-Xia Shen, Shen-Yu Ren, Yi-Zhuo Liu, Bo‐Xiao Tang, He-Bang Zhao, Yilin Liu, Shaowei Zhang, Hongwei Lin, Jin-Heng Li
DOI: 10.1039/d6cc02719a
Cited by: 3
References: 63

Abstract

/toluene system to afford 2-azadienes in high yields with excellent selectivity. Control experiments indicated that the synergistic cesium ion-directed deprotonation of the α-hydrogen of the ketonitrone generating a carbanion intermediate is the key step in the dehydration process. Moreover, 1-aminoindane, a privileged scaffold present in numerous pharmaceutical agents, is readily accessible through the selective reduction of 2-azadiene.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Synthesis of heterocyclic compounds

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
51
Pages
12954–12958
Publication date
1 January 2026
Language
EN