Oxidation pattern of tapinarof as a topical drug with potential to form Pi-stacking and dimers

Physical Chemistry Chemical Physics 2026 Open access

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Authors: Lucie Dostálková, Barbora Papoušková, Martina Zatloukalová, Martin Kabeláč, Jan Vacek, Romana Sokolová
DOI: 10.1039/d6cp01740a
Cited by: 1
References: 16

Abstract

The unique chemical structure of the therapeutic agent tapinarof (TPN) closely affects its reactivity and ability to interact. Its oxidative transformation leads to the formation of a keto group in the alkene part of TPN and then to a quinone and dimerization. Pi-stacking and H-bonds participate in the formation of non-covalent TPN-dimeric structures.

Fields of Study & Subjects

Pharmacological Receptor Mechanisms and Effects Drug Solubulity and Delivery Systems Free Radicals and Antioxidants

Publication details

Journal / source
Physical Chemistry Chemical Physics
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
33
Pages
19987–19991
Publication date
1 January 2026
Language
EN