Stoichiometry dependent modifications in synthetic heme peroxo reactivity with nitrosonium: a new paradigm for understanding heme mediated nitration chemistry

Dalton Transactions 2026

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Authors: Samith B. Jayawardana, Collin B. Gabel, Arya A Bhosale, Aruzhan Abdikaiym, Gbolagade Olajide, Shanuk Rajapakse, Tibor Szilvási, Brad S. Pierce, Gayan B. Wijeratne
DOI: 10.1039/d6dt00522e
Cited by: 2
References: 48

Abstract

radicals are shown to drive the nitration and oxidation of a series of bioinspired substrates. This stoichiometry-dependent reactivity shift highlights a long-proposed, but experimentally elusive principle governing interactions between heme-oxygen intermediates and nitrogen oxides, providing new mechanistic insight into nitrosative stress pathways relevant to analogous biological systems.

Fields of Study & Subjects

Metal-Catalyzed Oxygenation Mechanisms Hemoglobin structure and function Heme Oxygenase-1 and Carbon Monoxide

Publication details

Journal / source
Dalton Transactions
Publisher
Royal Society of Chemistry (RSC)
Volume
55
Issue
20
Pages
8025–8032
Publication date
1 January 2026
Language
EN