Electronic effects of 4′-aryl substitution in terpyridine copper( ii ) complexes: structural insights, DNA-binding affinity, and cytotoxic evaluation
Abstract
cytotoxicity studies (MTT assay) against MCF7 and HEK293 cell lines reveal dose-dependent growth inhibition, with complexes 2 and 3 exhibiting enhanced activity, correlating with their stronger ROS producing propensity. The ability to generate cellular ROS was also examined and complex 2 was found to be efficient in ROS generation in a cancer cell line. These results highlight the influence of aryl substitution on the structural, electronic, and biological properties of terpyridine-based copper(II) complexes.
Fields of Study & Subjects
Metal complexes synthesis and properties
Metal-Organic Frameworks: Synthesis and Applications
Ferrocene Chemistry and Applications
Publication details
- Journal / source
- Dalton Transactions
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 55
- Issue
- 29
- Pages
- 10850–10863
- Publication date
- 1 January 2026
- Language
- EN