A conserved glutamate orchestrates transitions between catalytic intermediates in [NiFe]-hydrogenase

EES Catalysis 2026 Open access

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Authors: Armel F. Tadjoung Waffo, Christian Lorent, Sagie Katz, Cornelius Constantin Maria Bernitzky, Janna Schoknecht, Marius Horch, Oliver Lenz, Giorgio Caserta, Ingo Zebger
DOI: 10.1039/d6ey00004e
Cited by: 1
References: 64

Abstract

A conserved glutamate in the second coordination sphere controls [NiFe]-hydrogenase catalysis by enabling the Ni a –L1 → Ni a –L2 transition. Its absence disrupts outer sphere protein rearrangements required for proton transfer and efficient catalysis.

Fields of Study & Subjects

Metalloenzymes and iron-sulfur proteins Asymmetric Hydrogenation and Catalysis Electrocatalysts for Energy Conversion

Publication details

Journal / source
EES Catalysis
Publisher
Royal Society of Chemistry (RSC)
Volume
4
Issue
4
Pages
981–994
Publication date
1 January 2026
Language
EN