Ligilactobacillus salivarius Li01 enhances gut microbiota-derived indole-3-propionic acid to alleviate 5-fluorouracil-induced diarrhea in mice

Food & Function 2026 Open access

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Authors: Pengyu Yin, Bo Qiu, Lvwan Xu, Siyuan Xie, Shuobo Zhang, Jingyi Zhang, Björn Berglund, Mingfei Yao, Lanjuan Li
DOI: 10.1039/d6fo00050a
Cited by: 2
References: 60

Abstract

Li01 administration alleviated 5-FU-induced diarrhea by mitigating inflammation and oxidative damage, and restoring intestinal barrier. Li01 exerted its benefits by elevating the level of gut microbiota-derived IPA, which activated the PXR.

Fields of Study & Subjects

Gut microbiota and health Oral health in cancer treatment Colorectal Cancer Treatments and Studies

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
7
Pages
3248–3264
Publication date
1 January 2026
Language
EN