Lactiplantibacillus plantarum KLDS1.0344 ameliorates depressive-like behavior in CUMS mice: integrative multi-omics evidence linking gut microbiota alterations to sphingolipid and glycerophospholipid metabolic pathways

Food & Function 2026

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Authors: Fangfei Dou, Yuxing Li, Wenqing Lv, Yuqi Sun, Meiqi Li, Bailiang Li, Yupeng Wang, Wei Yu
DOI: 10.1039/d6fo00143b
Cited by: 1
References: 47

Abstract

and alterations in other key taxa, together with marked changes in sphingolipid- and glycerophospholipid-related metabolic profiles. Correlation analysis suggested coordinated associations between microbial shifts and intestinal lipid metabolic features, supporting a candidate microbiota-metabolite framework related to the psychobiotic effects of KLDS1.0344. Overall, this study provides evidence supporting the psychobiotic potential of KLDS1.0344 and its possible application in functional foods for depression-related intervention.

Fields of Study & Subjects

Gut microbiota and health Gastrointestinal motility and disorders Sphingolipid Metabolism and Signaling

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
14
Pages
6369–6381
Publication date
1 January 2026
Language
EN