Neochlorogenic acid attenuates endothelial injury in diabetic ApoE −/− mice by suppressing NF-κB mediated NLRP3 inflammasome activation

Food & Function 2026

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Authors: Yung-Che Tsai, Kuei‐Chuan Chan, I-Ning Tsai, Ping-En Ko, Hui-En Hsu, Meng-Hsun Yu, Chau‐Jong Wang
DOI: 10.1039/d6fo00170j
Cited by: 1
References: 32

Abstract

mice, nCGA administration improved metabolic parameters, reduced vascular lipid deposition, and lowered serum low-density lipoprotein cholesterol (LDL-C) levels, accompanied by decreased expression of inflammatory markers. In conclusion, these findings demonstrate that nCGA is a promising natural therapeutic candidate for alleviating diabetes-associated vascular injury through targeted inhibition of NF-κB and the NLRP3 inflammasome signaling pathway.

Fields of Study & Subjects

Inflammasome and immune disorders Adipokines Inflammation and Metabolic Diseases Heme Oxygenase-1 and Carbon Monoxide

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
12
Pages
5506–5520
Publication date
1 January 2026
Language
EN