Ketogenic diet-derived faecal microbiota transplantation improved sensorimotor gating deficits in an acute NMDA-receptor antagonist model of schizophrenia in mice
Abstract
MK-801 (dizocilpine) to induce a schizophrenia-like sensorimotor gating deficit as measured by the pre-pulse inhibition (PPI) of startle. MK-801 reduced PPI, which was attenuated by the faecal microbial transplant derived from mice fed with a KD. We showed for the first time that FMT through inoculation with KD faeces improved a highly translatable behavioural endophenotype of schizophrenia. Our novel findings confirm that some of the beneficial effects of KDs in schizophrenia are mediated by the gut microbiota.
Fields of Study & Subjects
Gut microbiota and health
Diet and metabolism studies
Tryptophan and brain disorders
Publication details
- Journal / source
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 8
- Pages
- 3529–3536
- Publication date
- 1 January 2026
- Language
- EN