The hawthorn ( Crataegus pinnatifida ) procyanidin extract attenuates nonalcoholic fatty liver disease in mice via remodeling the bile acid profile driven by gut microbiota and regulating the FXR pathway
Abstract
unconjugated BAs (ωMCA, TαMCA, TβMCA, and DCA), which was related to the restoration of the HFD-induced dysbiosis. Mechanistically, HPC downregulated the expression of lipid synthesis protein SREBP1 by activating the hepatic FXR and CYP7A1 expressions, attributed to the controlling of the enterohepatic circulation mediated by the FXR-FGF15 pathway. Taken together, these findings substantiate that HPC exerts its ameliorative effect on NAFLD by modulating BA metabolism in NAFLD mice.
Fields of Study & Subjects
Botanical Studies and Applications
Phytochemical and Pharmacological Studies
Nutrition
Genetics
and Disease
Publication details
- Journal / source
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 13
- Pages
- 6108–6124
- Publication date
- 1 January 2026
- Language
- EN