Poria cocos polysaccharide alleviates multidrug-resistant Klebsiella pneumoniae -induced acute lung injury by modulating the gut–lung axis via gut microbiota remodeling

Food & Function 2026

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Authors: Yifei Xiang, Shuxin Zhu, Renhe Wang, Jingsheng Huang, Han Li, Dejia Dai, Yunmei Yang, Hao Hu, Yingyi Wei, Tingjun Hu, Jiakang He, 正敏 梁
DOI: 10.1039/d6fo01450j
Cited by: 4
References: 45

Abstract

< 0.05). Mechanistically, PCP restored intestinal barrier function by upregulating tight junction proteins (occludin and claudin-1) and mucosal defense factors (SIgA and MUC-2), and reversed gut dysbiosis by restoring microbial diversity and enriching beneficial taxa. These protective effects were largely attenuated in pseudo-germ-free mice, suggesting that the protection offered by PCP against MDR-KP-induced ALI is dependent on the gut microbiota. In conclusion, oral PCP alleviates MDR-KP-induced ALI through a gut microbiota-mediated pathway by remodeling the gut microbiota, reinforcing intestinal barrier integrity, and regulating the gut-lung axis, providing a novel gut-targeted therapeutic strategy against drug-resistant KP infections.

Fields of Study & Subjects

Gut microbiota and health Polysaccharides and Plant Cell Walls Immune Response and Inflammation

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
11
Pages
5032–5046
Publication date
1 January 2026
Language
EN