Bound polyphenols from carrot dietary fiber delay aging in Caenorhabditis elegans through the IIS pathway and metabolic remodeling

Food & Function 2026

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Authors: Jinghan Feng, Bing Zheng, Hui Ye, Jianhua Xie, Yi Chen, Xinyi Chen, Xiaobo Hu, Danyang Liu, Ruihong Dong, Qiang Yu
DOI: 10.1039/d6fo02372j
Cited by: 1
References: 54

Abstract

mutants confirmed that the effects of CDF-BP on promoting longevity depended on these pathways. Collectively, these findings identify CDF-BP as a bioactive modulator of longevity that acts through convergent regulation of stress response signaling and metabolic reprogramming, and further suggest that bound polyphenols may represent an underestimated target in nutritional strategies for healthy aging.

Fields of Study & Subjects

Genetics Aging and Longevity in Model Organisms Sirtuins and Resveratrol in Medicine Endoplasmic Reticulum Stress and Disease

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
18
Pages
8002–8015
Publication date
1 January 2026
Language
EN