Solvent recycling in solid-phase peptide synthesis (SPPS): combination of a swellable macroporous polystyrene (SMPS) resin and green binary solvents

Green Chemistry 2026 Open access

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Authors: Mani Kaushal, Sikabwe Noki, Yuxing Yang, Chaoyang Wang, Cheng Zhang, Alesandra Basso, Simona Serban, Dan Wu, Yanjun Li, Xiaokang Kou, Ashish Kumar, Anamika Sharma
+2 more Beatriz G. de la Torre, Fernando Albericio
DOI: 10.1039/d6gc01716a
Cited by: 3
References: 48

Abstract

Solid-phase peptide synthesis (SPPS) relies heavily on hazardous solvents, such as N , N ′-dimethylformamide (DMF), whose substitution by green solvents is proving more challenging than expected.

Fields of Study & Subjects

Chemical Synthesis and Analysis Supramolecular Self-Assembly in Materials Protein Hydrolysis and Bioactive Peptides

Publication details

Journal / source
Green Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
21
Pages
8956–8965
Publication date
1 January 2026
Language
EN