Evaluation of the acute toxicity of the choline chloride : urea deep eutectic solvent and its impact on the intestinal microbiota

Green Chemistry 2026 Open access

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Authors: Md Masudur Rahman, Adel Bou Alia, Minna Choi, Nicolas Trainel, Pranvera Krasniqi, Aurore Desmons, Catherine Cailleau, Françoise Mercier‐Nomé, Vincent Faivre, Natalie Fournier, AM Cassard, François‐Xavier Legrand
DOI: 10.1039/d6gc01988a
Cited by: 1
References: 86

Abstract

Acute oral exposure to ChCl : urea DES induces gut microbiota dysbiosis, disrupts the bile acid-FXR-liver axis, and triggers subclinical hepatic inflammation, revealing critical toxicological endpoints overlooked by classical safety markers.

Fields of Study & Subjects

Ionic liquids properties and applications Extraction and Separation Processes Chemical and Physical Properties in Aqueous Solutions

Publication details

Journal / source
Green Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
38
Pages
15242-15263
Publication date
1 January 2026
Language
EN