A tunable 50 MHz acoustic vortex tweezer for size-selective manipulation and cell pre-concentration
Abstract
= 1, 3, 5) to adjust the capture orbit diameter, ranging from 50 to 150 μm. Manufactured using deep reactive ion etching (DRIE) on monocrystalline silicon, the metasurface ensures lower energy loss and higher structural resolution compared to traditional polymer vortex devices. We demonstrate its multiple application modes: orbital rotation and size-selective manipulation of microparticles, as well as customized range pre-concentration of cells. This device creates a "protective cage" with a low-pressure core that has a variable range, allowing cells to aggregate into clusters. This silicon-based vortex platform is compatible with semiconductor processes, providing a universal label-free solution for biological sample analysis and high-sensitivity downstream detection in lab-on-a-chip systems.
Fields of Study & Subjects
Microfluidic and Bio-sensing Technologies
Ultrasound and Hyperthermia Applications
Microfluidic and Capillary Electrophoresis Applications
Publication details
- Journal / source
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 26
- Issue
- 10
- Pages
- 3184–3191
- Publication date
- 1 January 2026
- Language
- EN