A portable, low-cost, point-of-care DNA amplification kit with impedance-based detection for decentralized antimicrobial resistance diagnostics

Lab on a Chip 2026 Open access

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Authors: Koosha Karimi, Miriam Arroyo, Erin Chille, Timothy G. Stephens, Donal Barrett, Vicent Pelechano, Debashish Bhattacharya, mehdi javanmard
DOI: 10.1039/d6lc00062b
Cited by: 2
References: 35

Abstract

copies per μl) in a complex background DNA mixture demonstrated detection results that strongly correlated with quantitative PCR (qPCR). These findings demonstrate that the amplification kit achieves performance parity with gold-standard nucleic acid detection methods while offering portability, affordability, and ease of use. By enabling accurate, rapid, and decentralized diagnostics without reliance on laboratory infrastructure, this combined workflow holds promise for advancing infectious disease monitoring and antimicrobial resistance surveillance, among other applications, at the point of care.

Fields of Study & Subjects

Biosensors and Analytical Detection Advanced biosensing and bioanalysis techniques Innovative Microfluidic and Catalytic Techniques Innovation

Publication details

Journal / source
Lab on a Chip
Publisher
Royal Society of Chemistry (RSC)
Volume
26
Issue
6
Pages
2061–2073
Publication date
1 January 2026
Language
EN