A CRISPR–Cas12a amplified RNase activity sensor powered by gold nanoparticle–barcode DNA multipliers

Materials Advances 2026 Open access

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Authors: Sathishkumar Munusamy, Rana Jahani, Jun Chen, Shou Zhou, Juanhua Kong, Haiyan Zheng, Xiyun Guan
DOI: 10.1039/d6ma00316h
Cited by: 1
References: 49

Abstract

for RNase A. The sensor exhibited excellent specificity against structurally and functionally related biomolecules and demonstrated strong analytical performance when tested on serum and water samples, with recoveries obtained ranging from 104 to 110%. Owing to its modular substrate design and robust signal amplification, this DNA-assisted platform offers a versatile and clinically relevant tool for monitoring RNase A activity and can be readily adapted for detecting other nuclease-based biomarkers.

Fields of Study & Subjects

CRISPR and Genetic Engineering Advanced biosensing and bioanalysis techniques Biosensors and Analytical Detection

Publication details

Journal / source
Materials Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
7
Issue
10
Pages
4973–4982
Publication date
1 January 2026
Language
EN