Discovery of novel coumarin amphiphiles: dual-action antimicrobials with bacteria-mediated biofilm disruption and host-directed immunomodulation

RSC Medicinal Chemistry 2026 Open access

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Authors: Haiyang Zhang, Qun Tang, Qian Zhu, Weiwei Xu, Zhihao Wang, Zirui Jiao, Jiakun Zuo, Wei Jiang, Cuiqin HUANG, Huifang Yin, Xiangan Han, Wen Zhou
DOI: 10.1039/d6md00004e
Cited by: 0
References: 33

Abstract

Coumarin-derived amphipathic compounds were synthesised. Compound 15 shows potent anti- S. aureus , anti-biofilm and in vivo activities as a potential candidate.

Fields of Study & Subjects

Bacterial biofilms and quorum sensing Antimicrobial agents and applications Synthesis and biological activity

Publication details

Journal / source
RSC Medicinal Chemistry
Volume
17
Issue
4
Pages
1938–1949
Publication date
1 January 2026
Language
EN