Triclosan–isatin hybrids as potent anti-proliferative agents inducing S-phase arrest via DNA gyrase inhibition in triple-negative breast cancer

RSC Medicinal Chemistry 2026 Open access

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Authors: Shekhar, Asif Raza, Sukhmanpreet Kaur, Amit Anand, Arun K. Sharma, Vipan Kumar
DOI: 10.1039/d6md00013d
Cited by: 1
References: 26

Abstract

DNA gyrase B inhibition. Both exhibited significant suppression of DNA supercoiling, confirming strong binding affinity to the enzyme and suggesting a potential role in topoisomerase-mediated anticancer activity.

Fields of Study & Subjects

Click Chemistry and Applications Synthesis and Characterization of Heterocyclic Compounds Synthesis and biological activity

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
5
Pages
2473–2485
Publication date
1 January 2026
Language
EN