Recent advances in the development of acridine-based hybrids with antiproliferative activity
Abstract
experiments, reflecting their multifaceted pharmacological profiles. Computational approaches, such as molecular docking, molecular dynamics, and quantitative SAR (QSAR), have further contributed mechanistic insights and informed rational optimization of pharmacokinetic and pharmacodynamic properties. The review concludes by addressing current challenges and future directions, emphasizing the transformative potential of integrating artificial intelligence (AI) with computer-aided drug design (CADD) and advanced delivery systems. By compiling these developments, this work aims to serve as a useful reference to assist researchers in the design of new, more effective acridine-based anticancer agents.
Fields of Study & Subjects
Cancer therapeutics and mechanisms
Synthesis and biological activity
Synthesis and Biological Activity
Publication details
- Journal / source
- RSC Medicinal Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 6
- Pages
- 2768–2849
- Publication date
- 1 January 2026
- Language
- EN