Phenoxyacetic acid scaffold as a platform for dual anticonvulsant and anti-inflammatory drug design

), supporting effective modulation of inflammatory signaling. Compound 7b also exhibited strong analgesic activity, increasing nociceptive latency by 37.76% at 30 min and reaching 52.08% at 120 min in the hot-plate assay. Remarkable anticonvulsant efficacy was observed in both the pentylenetetrazole (PTZ) induced seizure model and pilocarpine-induced seizure model, where 7b afforded 90% seizure protection with complete prevention of mortality, delayed seizure onset by 156.43%, reduced seizure severity by 70.53%, and achieved 100% survival, surpassing sodium valproate. Mechanistically, 7b markedly attenuated hippocampal neuroinflammation and excitotoxicity, reducing TNF-α, IL-6, and glutamate levels while suppressing glial activation markers glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1, confirming pronounced neuroprotective and anti-neuroinflammatory effects.