Development of novel chalcone-based quinazoline derivatives as dual VEGFR-2 and EGFR inhibitors

RSC Medicinal Chemistry 2026 Open access

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Authors: Zainab Elsayed, Haytham O. Tawfik, Loah R. Hemeda, Mohamed S. Nafie, Hadia Almahli, Rehan Monir, Ikhlas A Sindi, Eslam Elkaeed, Mostafa M. Elbadawi, Mahmoud A. El Hassab, Wagdy M. Eldehna
DOI: 10.1039/d6md00179c
Cited by: 4
References: 49

Abstract

ADME and toxicity tests demonstrated good drug-likeness, pharmacokinetic characteristics, and a satisfactory safety profile. Overall, these results show that quinazoline-chalcone hybrids are effective dual EGFR/VEGFR-2 inhibitors with strong anti-cancer potential.

Fields of Study & Subjects

Quinazolinone synthesis and applications HER2/EGFR in Cancer Research Angiogenesis and VEGF in Cancer

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
6
Pages
2984–3002
Publication date
1 January 2026
Language
EN