Alkyl chain length as a molecular switch: from supramolecular reprogramming to biointerface modulation in α-aminophosphonate assemblies

Molecular Systems Design & Engineering 2026

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Authors: Rawda Kholany, Alaa A. Mardini, Ksenia Shakirova, Daut Islamov, Alexander V. Gerasimov, Alexander E. Klimovitskii, Alena A. Vavilova, Olga A. Mostovaya, Asiya F. Gazizova, Alexandra Dmitrievna Voloshina, Anna P. Lyubina, Konstantin A. Petrov
+1 more Ivan I. Stoikov
DOI: 10.1039/d6me00038j
Cited by: 1
References: 95

Abstract

Alkyl chain length acts as a molecular switch, not merely a lipophilicity modifier, in dialkyl phosphonates. Extending ethyl to butyl shifts dimer to tetramer assembly, alters electronics, and aggregation behavior, yet preserves low cytotoxicity.

Fields of Study & Subjects

Organophosphorus compounds synthesis DNA and Nucleic Acid Chemistry Nuclear Structure and Function

Publication details

Journal / source
Molecular Systems Design & Engineering
Publisher
Royal Society of Chemistry (RSC)
Volume
11
Issue
8
Pages
782–795
Publication date
1 January 2026
Language
EN