Mechanosynthesis of cocrystals and coamorphous binary drug–drug systems with apremilast core: structural and biological studies

RSC Mechanochemistry 2026 Open access

Read full text
Authors: Katarzyna Trzeciak, R. Dolot, Marta Katarzyna Dudek, Ewelina Wielgus, S. Kazmierski, Piotr Paluch, J. (Jiří) Czernek, Jiřı́ Brus, Katarzyna Wiktorska, I. Wadas, K. Głowacka, A. Lange
+1 more Marek J. Potrzebowski
DOI: 10.1039/d6mr00014b
Cited by: 1
References: 64

Abstract

New solid-state forms of apremilast, an effective oral medication used in the treatment of psoriasis in combination with nonsteroidal anti-inflammatory and analgesic antipyretic drugs as co-formers obtained through a mechanochemical process.

Fields of Study & Subjects

Crystallography and molecular interactions Supramolecular Chemistry and Complexes Calcium Carbonate Crystallization and Inhibition

Publication details

Journal / source
RSC Mechanochemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
3
Issue
3
Pages
444–458
Publication date
1 January 2026
Language
EN