Cholesterol-containing ionizable lipids for safe and efficient mRNA delivery via lipid nanoparticles

New Journal of Chemistry 2026

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Authors: Liang Xie, Haiyang Li, Jiangsheng Xu, Fang Zeng, Shuizhu Wu
DOI: 10.1039/d6nj00164e
Cited by: 1
References: 55

Abstract

Ionizable lipids with sterol-containing tails enable efficient mRNA delivery, high protein expression, and improved biosafety, thereby providing a crucial foundation for the development of low-immunogenicity mRNA formulations.

Fields of Study & Subjects

RNA Interference and Gene Delivery Lipid Membrane Structure and Behavior Nanoparticle-Based Drug Delivery

Publication details

Journal / source
New Journal of Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
50
Issue
20
Pages
8608–8618
Publication date
1 January 2026
Language
EN