Structural determination of natural products at speeds and scale of high-throughput screening

Covering 2000 up to 2025.This review assesses analytical techniques available for routine structural elucidation of small molecules as part of high-throughput screening campaigns of natural product libraries. The emphasis is on the speed and scale of task management and highlights advances in technologies and library tools that enable the structural elucidation of complex molecules on small-scale and rapid timelines. We present the state of the art in the natural product field and provide a critical assessment of available techniques and tools, with a focus on the ability to analyze large numbers of samples in short timelines that can meet the speed and scale of high-throughput screening.