Exploring gefitinib to enhance endocytosis of antibodies and nucleic acid aptamers targeting EGFR in glioblastoma

Nanoscale 2026 Open access

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Authors: Charlène D'Ancona, Elisabete Cruz da Silva, Léa Denechere, Hélène Justiniano, Valérie Calco, Ludovic Richert, Romain Vauchelles, Dilara Sensoy, Candice Dussouillez, Cendrine Seguin, Pascal Villa, François Daubeuf
+5 more Antoine Kichler, Sylvie Fournel, Halina Anton, Maxime Lehmann, Laurence Choulier
DOI: 10.1039/d6nr00420b
Cited by: 1
References: 73

Abstract

Gefitinib induces massive EGFR endocytosis in glioblastoma, enhancing EGFR-targeting antibody and aptamer internalization, boosting antibody-drug conjugates and aptamer-siRNA conjugates in vitro .

Fields of Study & Subjects

Monoclonal and Polyclonal Antibodies Research HER2/EGFR in Cancer Research Glioma Diagnosis and Treatment

Publication details

Journal / source
Nanoscale
Publisher
Royal Society of Chemistry (RSC)
Volume
18
Issue
30
Pages
16017–16033
Publication date
1 January 2026
Language
EN