Osteopontin-loaded nanoarchaeosomes for enhanced osteogenesis and bone regeneration in osteoporotic zebrafish models

Nanoscale 2026

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Authors: B Mukilarasi, Anisha Kabir, S. Sathik Basha, Bhagyashree Ashok Bhoir, Zufu Lu, Vimalraj Selvaraj, Hala Zreiqat, Swathi Sudhakar
DOI: 10.1039/d6nr00629a
Cited by: 1
References: 54

Abstract

studies demonstrated high biocompatibility in zebrafish embryos, along with increased bone count, mineral density, and regenerative capacity in both fin-fracture and amputation models. Furthermore, zebrafish models of osteoporosis treated with NAO showed improved Ca : P ratios, enhanced mineralization, and upregulation of key osteogenic genes, indicating robust bone regeneration. Collectively, these findings establish osteopontin-loaded nanoarchaeosomes as an efficient nanoplatform capable of sustaining osteogenic signaling and accelerating bone repair, offering a therapeutic strategy to overcome the limitations of current osteoporosis treatment.

Fields of Study & Subjects

Bone and Dental Protein Studies Bone Tissue Engineering Materials Calcium Carbonate Crystallization and Inhibition

Publication details

Journal / source
Nanoscale
Publisher
Royal Society of Chemistry (RSC)
Volume
18
Issue
24
Pages
13020–13033
Publication date
1 January 2026
Language
EN