Fibrin-targeted and pH-responsive liposomes for synergistic thrombolysis and thrombotic microenvironment reprogramming
Abstract
demonstrated that tLipo@UA achieved efficient thrombus targeting and responsive drug release. The released uPA effectively dissolved thrombi, while the co-delivered ASA modulated the thrombotic microenvironment by suppressing the inflammatory cytokine release, thereby exhibiting synergistic thrombolytic and anti-inflammatory effects. Encapsulation of uPA significantly prolonged its circulation time and enhanced its localized efficacy. Furthermore, this system showed a favorable biosafety profile. Collectively, tLipo@UA presents a promising strategy for enhancing thrombolytic potency and achieving microenvironment reprogramming with reduced off-target risks, offering a rational design for dual-function drug carriers in the treatment of thrombotic diseases.
Fields of Study & Subjects
Protease and Inhibitor Mechanisms
Nanoparticle-Based Drug Delivery
RNA Interference and Gene Delivery
Publication details
- Journal / source
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 18
- Issue
- 21
- Pages
- 11271–11279
- Publication date
- 1 January 2026
- Language
- EN