Total synthesis of ( ent )-linderolide E and ( ent )-15-hydroxy- and 15-acetoxyisogermafurenolides, and structural revision of ( ent )-linderolide E

Organic & Biomolecular Chemistry 2026

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Authors: Anisha Suresh, Mahendra R. Shingole, Krishna P. Kaliappan
DOI: 10.1039/d6ob00001k
Cited by: 2
References: 30

Abstract

-isogermafurenolide. The route features four key transformations: a Tanabe lactonisation for lactone formation, a site-selective allylic oxidation, a Luche reduction, and a ring-closing metathesis constructing the eudesmane framework. Additionally, single-crystal X-ray diffraction analysis of synthetic material establishes a revised structural assignment for natural linderolide E.

Fields of Study & Subjects

Sesquiterpenes and Asteraceae Studies Plant-derived Lignans Synthesis and Bioactivity Plant Toxicity and Pharmacological Properties

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
8
Pages
1678–1682
Publication date
1 January 2026
Language
EN