Palladium-catalyzed difluoromethylcarbonylation of aryl iodides

Organic & Biomolecular Chemistry 2026

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Authors: Yijie Wei, Jinxu Dong, Xiaohong Wen, Xiaodong Xiong, Xiaojun Zeng
DOI: 10.1039/d6ob00006a
Cited by: 0
References: 35

Abstract

We report a palladium-catalyzed carbonylative difluoromethylation of aryl iodides with (DMPU) 2 Zn(CF 2 H) 2 under 1 atm CO, giving aryl difluoromethyl ketones in good yields, with broad tolerance, late-stage modification, and facile derivatization.

Fields of Study & Subjects

Fluorine in Organic Chemistry Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic & Biomolecular Chemistry
Volume
24
Issue
9
Pages
1803–1807
Publication date
1 January 2026
Language
EN