Asymmetric hydrogenation of N-heterocycles for pharmaceutical intermediates: synthetic strategies and theoretical perspectives

Organic & Biomolecular Chemistry 2026

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Authors: Yiting Pu, Tong Shao, Shaohua Yang, Haneol Cho, Chansoo Kim, Uk Sim, Shuihua Wang, H. J. Choi
DOI: 10.1039/d6ob00016a
Cited by: 1
References: 86

Abstract

hydride transfer) in organocatalysis. By bridging empirical synthetic results with these theoretical insights, this work aims to provide a comprehensive guide for selecting appropriate catalytic systems and facilitating the rational design of next-generation catalysts for high-value chiral heterocycles.

Fields of Study & Subjects

Asymmetric Hydrogenation and Catalysis Coordination Chemistry and Organometallics Surface Chemistry and Catalysis

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
14
Pages
2781–2797
Publication date
1 January 2026
Language
EN