Bisaspochalasin F: a tetrahydrofuran ring-fused cytochalasan homodimer from an endophytic Aspergillus flavipes as a Ca v 3.2 inhibitor

Organic & Biomolecular Chemistry 2026

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Authors: Li Wang, Rui Liu, Zhiyin Yu, Chun-Jun Hou, Sheng-Xiong Huang, Yin Nian, Jing Yang
DOI: 10.1039/d6ob00028b
Cited by: 0
References: 31

Abstract

Bisaspochalasin F (1) is an undescribed cytochalasan homodimer featuring a bridging tetrahydrofuran ring. It represents the first cytochalasan modulator of T-type calcium channels, demonstrating potent inhibition of Ca v 3.2 (IC 50 : 6.99 ± 0.23 µM).

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Bioactive Natural Diterpenoids Research Plant and fungal interactions

Publication details

Journal / source
Organic & Biomolecular Chemistry
Volume
24
Issue
10
Pages
2096–2101
Publication date
1 January 2026
Language
EN