Synthesis and biological evaluation of fluorinated bergenin derivatives
Abstract
Bergenin is a natural C-glycoside with multi-target therapeutic potential. Herein, a series of 21 novel derivatives were designed and synthesized through direct hydroxy-fluorination and the incorporation of fluorinated building blocks. Biological activity evaluation results demonstrated that, except for ether derivatives, most fluorine-containing derivatives exhibited superior anti-inflammatory and antitussive activities compared with bergenin, and among these derivatives, the C4-fluorinated ones (1b, 1d, 2a, 2d and 2e) showed the most prominent activity.
Fields of Study & Subjects
Phytochemistry and Bioactivity Studies
Enzyme function and inhibition
Phytochemistry and Bioactive Compounds
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 9
- Pages
- 1852–1856
- Publication date
- 1 January 2026
- Language
- EN