Palladium-catalyzed reductive Heck cyclization of alkene-tethered carbamoyl chlorides to access CH 3 - and CH 2 D-functionalized oxindoles

Organic & Biomolecular Chemistry 2026

View at publisher
Authors: Junjie Pan, Zi-Yi Wang, Bingxiao Li, Chunjie Ni, Chen Chen
DOI: 10.1039/d6ob00032k
Cited by: 1
References: 48

Abstract

D-functionalized oxindoles. Notable features of this transformation include its robust scalability and good functional group tolerance. The utility of this approach is further underscored by its successful adaptation to one-pot procedures, offering diverse synthetic pathways to medicinally relevant architectures.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
8
Pages
1605–1608
Publication date
1 January 2026
Language
EN