Rh III -catalyzed C–H heteroarylation and C–N cleavage: direct access to C2-heteroarylated (NH)-indoles

Organic & Biomolecular Chemistry 2026

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Authors: Zhen-Ang Liu, Guan Xiao, Xiao-Wen Su, Yu-Tong Dong, Huaiwei Wang
DOI: 10.1039/d6ob00059b
Cited by: 0
References: 132

Abstract

-(2,6-difluoroaryl) amide auxiliary with heterocyclic boronates, followed by auxiliary cleavage, offering an efficient route to biheteroaryl derivatives containing (NH)-indole and heterocyclic moieties. This catalytic methodology tolerated a diverse range of heterocyclic boronates and indoles well. Successful late-stage modification of the antimigraine drug sumatriptan further highlights its potential utility in the preparation of indole-based pharmaceutical molecules.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Sulfur-Based Synthesis Techniques Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic & Biomolecular Chemistry
Volume
24
Issue
14
Pages
2951–2962
Publication date
1 January 2026
Language
EN