Tunable synthesis of oxindoles and sulfonated oxindoles via photoredox-catalyzed C–H/C–H coupling
Abstract
-arylacrylamides, yielding either oxindoles or sulfonated oxindoles in moderate to good yields through simple DABSO modulation. The method exhibits broad substrate compatibility, accommodating a wide range of arenes including electron-rich, electron-deficient, and sterically hindered motifs, as well as complex pharmacophore-bearing derivatives. Mechanistic studies confirm a radical-based pathway involving aryl radical intermediates, highlighting the versatility and selectivity of this tunable synthetic platform for accessing structurally diverse oxindole scaffolds with potential pharmaceutical relevance.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Volume
- 24
- Issue
- 13
- Pages
- 2732–2741
- Publication date
- 1 January 2026
- Language
- EN