Photoredox radical annulation of aroyl sulfoxonium ylides and alkynes for 1-naphthol assembly
Abstract
The [4 + 2] annulation of sulfoxonium ylides with alkynes provides direct access to valuable 1-naphthol derivatives. To overcome the reliance of traditional methods on transition-metal catalysts and harsh conditions, we report a novel and mild photoredox-catalyzed [4 + 2] annulation reaction. This strategy enables efficient and rapid construction of diverse naphthol scaffolds with excellent chemo- and regioselectivity. Beyond classical ionic pathways, the unique radical reactivity of sulfoxonium ylides opens new avenues for their application in synthesizing a wide range of heterocycles.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 9
- Pages
- 1798–1802
- Publication date
- 1 January 2026
- Language
- EN