Chiral borophosphate catalyzed asymmetric hydroamination of alkenes
Abstract
Chiral pyrrolidines are key motifs in natural products and pharmaceutically active intermediates. Herein, we report a metal-free enantioselective intramolecular hydroamination of alkenes catalyzed by a chiral borophosphate. This chiral frustrated Lewis pair (FLP)-type catalyst outperforms chiral phosphoric acid alone, furnishing chiral pyrrolidines in up to 96% yield and 95% ee. This work extends the utility of chiral FLP catalysis to non-reductive asymmetric cyclization reactions.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Organoboron and organosilicon chemistry
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 10
- Pages
- 2023–2027
- Publication date
- 1 January 2026
- Language
- EN