Chromatographic purification of N–H ketimines via suppression of hydrolysis using dried silica gel and Et 3 N
Abstract
Hydrolytic decomposition of N–H ketimines during silica gel chromatography is prevented by using vacuum-dried silica and Et 3 N-containing eluents. This protocol facilitates the reliable purification of various sensitive N–H ketimines.
Fields of Study & Subjects
Analytical Chemistry and Chromatography
Advanced Synthetic Organic Chemistry
Chemical Synthesis and Reactions
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Volume
- 24
- Issue
- 11
- Pages
- 2316–2323
- Publication date
- 1 January 2026
- Language
- EN