Biocatalytic synthesis of heterobiaryl sulfoxides: a comparative study between Baeyer–Villiger monooxygenases and unspecific peroxygenases

Organic & Biomolecular Chemistry 2026 Open access

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Authors: Pablo Vázquez-Domínguez, Julia Carrión-González, Desirée García-Requena, Marco W. Fraaije, Nikola Lončar, Rosario Fernández, Katrin Scheibner, Ana Gutierrez, Alejandro Gonzalez-Benjumea, Abel Ros, Gonzalo de Gonzalo
DOI: 10.1039/d6ob00171h
Cited by: 1
References: 46

Abstract

at 50 mM substrate concentration without enantioselectivity loss. Overall, pyrrole-based sulfides displayed higher optical purities than indole analogues under BVMO catalysis, whereas UPOs excelled in terms of productivity and operational simplicity. Selected BVMO- and UPO-catalyzed reactions were successfully scaled up, demonstrating the practical applicability of these biocatalytic systems. These results highlight the complementary strengths of UPOs and BVMOs for the efficient and selective synthesis of chiral heterobiaryl sulfoxides.

Fields of Study & Subjects

Enzyme-mediated dye degradation Enzyme Catalysis and Immobilization Advanced oxidation water treatment

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
11
Pages
2345–2352
Publication date
1 January 2026
Language
EN