Organocatalytic regio- and stereoselective synthesis of chiral tetrasubstituted α-amino allenoates by γ-addition of β,γ-alkynyl-α-imino esters with pyrazolones

Organic & Biomolecular Chemistry 2026

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Authors: Zhenghua Zhou, Yongqiang Xu, Wenkai Li, Jingping Qu, Yuhan Zhou, Baomin Wang
DOI: 10.1039/d6ob00191b
Cited by: 0
References: 51

Abstract

Herein, we report a bis-dihydroquinine-catalyzed asymmetric nucleophilic addition of pyrazolones to β,γ-alkynyl-α-imino esters. This method enables the efficient synthesis of allenylpyrazolone derivatives featuring adjacent quaternary stereocenters and axially chiral tetrasubstituted allene motifs in high yields with excellent regio-, diastereo-, and enantioselectivities.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Axial and Atropisomeric Chirality Synthesis Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Organic & Biomolecular Chemistry
Volume
24
Issue
14
Pages
2888–2892
Publication date
1 January 2026
Language
EN